We've only got top-view rectangles and a tool centre mark. The carton note specifies support direction, but the layer drawing doesn't show it.

Build that combined drawing for packaging and your integrator. Include a repeated, unrotated layer as a simpler candidate; it may suit the support direction better

The repeated arrangement remains a candidate, not an accepted solution. Its support and load stability still need assessment for the cartons with their actual contents.

Agreed; I meant a comparison option. Packaging must assess both arrangements with the specified cartons and contents, including support and stability

I thought alternating layers always made a stronger stack. Is that too simple?

Too general. The arrangement changes where loads pass through the cartons. Your packaging reviewer needs the actual construction and support geometry to judge it

The layer overlay shows carton edges above gaps below. That gives me something specific to mark for packaging instead of saying the pattern feels wrong.